Canadian born country signer, Terri Clark, on the reality of witnessing a family member go through the trials of a cancer diagnosis and therapy. Clark's mother was diagnosed in 2007 and died three short years later in 2010. To read more on her story, check out: http://bit.ly/2JPRJLr
In 1902, German biologist Theodore Boveri discovered that chromosomal damage eventually leads to the formation of cancer as it prevents cells from properly dividing. His findings became the foundation to understanding how cancer works. Since then, scientists from around the world have introduced us to a whole new level of cancer research that we know of today. Read more here: http://bit.ly/2qkjNhc
Researchers from Mary University in London have been able to genetically engineer a flu virus (pictured below) to successfully attach pancreatic cancer. Pancreatic cancer is one of the most common cancers in the United States, taking the lives of over 43,000 in 2017. Read more about this here: http://bit.ly/2qhEEBR
A cancer diagnosis goes beyond just the diagnosed patient. The diagnosis of a loved one affects family members and close friends. Read this encouraging speech made by former Vice President, Joe Biden on how he has dealt with tragedy and loss. This speech is based on his own experiences after losing a son to brain cancer and his wife and daughter to a tragic car accident. http://bit.ly/2D3zylg
Ever wonder about the origin of the word cancer? Hippocrates, the "Father of Medicine," compared cancer to a crab. He gave the disease the name of karkinos, which is the greek word for crab. One reason being is that a crab's shell is not not easily destroyed - just as cancer is not either. http://bit.ly/2PPp4s8
Co-winners of the 2018 Nobel Prize in Physiology or Medicine, Dr. James Allison and Dr. Tasuku Honjo were pioneers in the development of immunotherapy as a novel treatment for cancer. Specifically, they both discovered proteins that acted as brakes on the immune system. These brakes could then be released to allow the body's immune system to better identify and eliminate cancer cells. To learn more about there research, visit: http://bit.ly/2yspb6p
To see more cancer charts and statistics on how the US compares to the rest of the world, visit: http://bit.ly/2ComchY
Watch sportscaster Stuart Scott deliver a fantastic acceptance speech for his Jimmy V Award at the 2014 ESPYs in the midst of a GI cancer diagonsis: http://bit.ly/2Egpyqd
Circulating tumor cells (red) are often the malicious precursors of tumor metastasis. In search of a solution, Harvard researchers reengineered a pathogen-capture technology called FcMBL and applied it to magnetic beads (grey). This combination was shown to capture over 90% of CTCs in vitro. While the FcMBL component of the bead allows it to recognize and attach specific carbohydrates found in abundance on many cancer cells, its magnetic property allows it to be directed and pulled out of the system. Learn more here: http://bit.ly/2pIJI1R
Original image: Wyss Institute, Harvard University
In light of October being breast cancer awareness month, here is a post to contribute to the cause. At the age of 36, Susan G. Komen passed away from breast cancer. In memory of her older sister, Nancy Brinker founded the Susan G. Komen Breast Cancer Foundation in 1982. Today, the Susan G. Komen Foundation is one of the largest organizations determined to fight breast cancer. Learn more bout the accomplishments of the foundation here from the founder herself: http://sgk.mn/2RlQdnQ
Can robots fight off cancer? In a major cancer breakthrough earlier this year, Arizona State University (ASU) researchers collaborated with researchers from the Chinese Academy of Sciences, to program nanorobots (pictured in silver) and demolish cancer tumors. These programmed nanorobots cut off the blood supply (pictured in red) of cancerous tumors, which then end up shrinking and are ultimately destroyed. This new technology is showing to be very promising for several types of cancers since, “tumor-feeding blood vessels are essentially the same,” said Hao Yan, director of the Molecular Design and Biomimetics program at ASU. http://bit.ly/2OsttE9
Susanna Greer, PhD, is the director of the clinical cancer research, nutrition, and immunology programs at the American Cancer Society. Her current research in immunotherapy for cancer is focused on CAR T-cell therapy. T-cells are engineered into CAR T-cells, which fight to attack leukemia and other possible blood cancers.
We all have heard that regular and habitual exercise has many health benefits, but a recent study shows that it can lower the risk of developing 13 specific types of cancer. It is proven that at least 30 mins of daily exercise can help lower levels of hormones associated with cancer development, reduce inflammation, and improve the immune system response to foreign invaders.
In 2012, Jennifer Doudna and her colleague, Emmanuelle Charpentier, published a method of genome editing that changed the landscape of molecular biology research. The CRISPR-Cas9 system is a revolutionary new tool being used at an ever accelerating rate to understand the hidden secrets of human biology. For a review of how it works and its scientific applications, hear from the creator herself in this awesome TED Talk: https://goo.gl/A5zBuP
The CRISPR-Cas9 system (seen here in green and gold around purple DNA) is taking cancer research to the next level. This system was originally discovered as a defense mechanism used by bacteria against viruses, but in 2012, scientists published an epic paper describing it as a potent gene editing tool. While gene therapy is but one potential application of the CRISPR-Cas9 system, it's an even more effective tool used by lab scientists to execute experiments on cancer cells and other model organisms. Learn more about it in this Science video and article: https://goo.gl/v8ZvZJ
Dr. Laurie Glimcher is the President and CEO of the prestigious Dana-Farber Cancer Institute in Boston, MA. Prior to her appointment in 2016, her research focused on T-cell differentiation. Her discoveries helped develop our understanding not only of cancer immunotherapy, but also of IBS, HIV, and osteoporosis. Read her 2014 interview back when she was Dean of Weill Cornell Medicine: https://goo.gl/AabUJR
In the early days of cancer therapy, our options were far more grim than they are today. Take a look at this diagram from Dr. William Halsted's article published in 1894 where he describes his "radical mastectomy" technique. These hugely invasive and disfiguring surgeries sometimes resulted in the removal ribs, collarbones, and entire arms. We've thankfully come a long way since then. Learn more: https://goo.gl/cfquNm
The first successful bone marrow transplant was performed by Dr. E. Donnall Thomas in the late 1950s. Leukemia and other blood cancers were once seen as untreatable, but thanks to the remarkable work of Dr. Thomas, many patients are now living with hope daily. In 1990 he was awarded the Nobel Prize in medicine for his extraordinary achievement. To this day, bone marrow transplants are viewed as one of the world's most signifiant medical advances. Watch this video and learn more about the impressive work of Dr. Thomas here: https://goo.gl/HNdy8c
Australian researchers have recently developed a drug that can put cancer protein cells to sleep. KAT6A and KAT6B (in blue) proteins are associated with the growth of several blood cancers. These newly developed drugs (in pink) have the ability to inhibit these type of cancer driving proteins. Something exciting is that these drugs also do not damage other healthy cells, which is a common side effect of traditional chemotherapy. Read more about this remarkable cancer breakthrough! Source: https://goo.gl/niJFUs
After her grandfather passed away from stomach chancer, Gertrude Elion committed herself to work in the sciences to ensure that fewer people experience what her grandfather did. Elion studied a class of molecules called purines to effectively create a chemotherapy for leukemia. She was awarded the Nobel prize for science in 1988. Read her inspiring and impressive story here: https://goo.gl/9DXKh4
Getting enough hours of sleep daily is important for our overall health, but did you know it can lower the risk of cancer? Also, proper sleep may help improve the prognosis of cancer for those who are currently fighting the disease: https://goo.gl/ZBZcjt
In case you didn’t know already, Seahawks quarterback Russell Wilson spends his Tuesdays during the regular season visiting patients at the Seattle Children’s Hospital. Wilson is a huge advocate for pediatric cancer research having raised millions of dollars for charities such as Strong Against Cancer in his 6 years as a Seahawk. Read more about his story here: https://goo.gl/mh35H6
Chimeric Antigen T-Cell (CAR T-Cell) therapy promises to be one of the biggest cancer breakthroughs in the early 21st century. The idea is simple: harvest the patient’s natural immune cells (seen here in yellow), re-engineer them to recognize and target cancer cells for destruction (green), and release them back into the body to do their job. But like many new therapies, the implementation hasn’t been as smooth as we would have hoped. Read more about the basics of CAR T-Cell therapy in this interview with Dr. Sattva S. Neelapu, M.D. https://goo.gl/G7rVPE
The unsung hero of DNA: Rosalind Franklin. Before Watson and Crick’s discovery of DNA structure, Franklin poured in years of painstaking work to develop a reliable method of x-ray imaging. Her data was later used by Watson and Crick to complete their double-helix hypothesis. Having passed away prior to 1962 when Watson, Crick, and Maurice Wilkins were awarded the Nobel Prize for their DNA work, Franklin has largely been overlooked despite her invaluable contributions to this field. Learn more about her story in this video: https://goo.gl/RfSu5U
Maintaining mental health is a huge and often overlooked component of successful cancer treatment. Thankfully, research into palliative care is creating valuable insight for how we can improve mental and physical health outcomes in cancer patients: https://goo.gl/wocaXZ
In one of the most inspirational speeches of all time, legendary college basketball coach Jim Valvano reminded us, “To spend each day with some laughter and some thought. To get your emotions going. To be enthusiastic every day.” The V Foundation has awarded more than $200 million in grants for cancer research since it was established on the day of his speech in 1993. If you have 10 minutes to spare, do yourself a favor and watch this: https://goo.gl/Sos8bb
One of the biggest limitations with traditional bio-imaging is that most methods only capture a static snapshot of the tissue. In 2013, Berkley scientists created a new technique called kinetic mass spectrometry imaging (kMSI) which allowed them to see dynamic changes in a single tissue sample. This image reveals real time changes in cancer metabolism by showing tumor distribution of newly synthesized (blue/purple) versus pre-existing (red/yellow/green) lipids.
With this quote from his bestselling book "Being Mortal," Dr. Atul Gawande highlights one of the greatest pitfalls of cancer care in the US today: our inability to appropriately talk about death during treatment. Interestingly fact - Dr. Gawande recently began his stint as CEO of the joint healthcare venture between J.P. Morgan, Amazon, and Berkshire Hathaway: https://goo.gl/41Udb7
While overall incidence of pediatric cancer has slowly increased by 0.6% per year since 1975, the pediatric cancer death rate has declined by over 66% since 1969. And remarkably, the cure rate for childhood acute lymphocytic leukemia (ALL) is approaching an astonishing 90% thanks to recent improvements in chemotherapy, stem cell transplants, and clinical trials.
Activist and philanthropist Mary Lasker completely redefined the landscape of cancer awareness in the mid-20th century. She ignited a new era of cancer patient advocacy and public funding for cancer research as evidenced by the establishment of the American Cancer Society and a boost of the NIH annual budget from $2.4 million in 1945 to $5.5 BILLION in 1985. Learn more about the Lasker legacy in this video: https://youtu.be/ko714y_7zxo?t=3m
Immunofluorescence microscopy is a technique used by molecular biologists to visualize internal components of tissues and cells. One such component gaining popularity in cancer research involves epigenetics - the study of DNA modifications that do not alter the core sequence. This breast cancer sample highlights the variety of epigenetic changes that can happen within a single tumor (seen in green, yellow, and red), and adds to the growing body of knowledge for scientists to create new cancer cures.
Original image: Scaffidi Lab, The Francis Crick Institute
Dr. John T. Schiller, co-recipient of the 2017 Lasker-DeBakey Clinical Medical Research Award, is one of the pioneering developers of the HPV vaccine. Watch how it works and how it was developed here: https://goo.gl/HmZoc3
This fossilized metatarsal came from an ancient human species around 1.7 million years ago. The evident pathology on the fossil was determined to be cancer of the bone, also known as osteosarcoma. This and other ancient fossils have shown us that cancer has been around millions of years before modern society: https://goo.gl/XrJscj
In 2012, Emma became the first pediatric patient, just 6 years old at the time, to undergo experimental CAR-T cell immunotherapy to treat her acute lymphoblastic leukemia (ALL). Today, she remains 6 years cancer free and serves as living proof that we are on the cusp of delivering long lasting therapies for some of the most aggressive cancers. Read her story here: https://goo.gl/STScPr
This intracellular protein complex, the apoptosome, is a critical component in the early stages of apoptosis (programmed cell death). Some cancer cells have the ability to impede this process, thus preventing their own destruction. There are multiple arms of cancer research that are attempting to induce apoptosis in cancer cells through chemo and immunotherapies: https://goo.gl/JC6iof
Dr. Bernadine Healy became the first female director of the NIH in 1991, and remains the only woman to have served as director to this day. Among her many accomplishments, Dr. Healy spearheaded the NIH Women's Health Initiative allocating $500 million for research into diseases that disproportionately affect women. Sadly, she died of recurrent brain cancer (glioma) in 2011, but her lifelong commitment to leadership in medicine remains as inspiring as ever: https://goo.gl/ENaU1Y
Did you know there are over 600 active immunotherapy trials for cancer in the US right now? If you or a loved one need a tool to look up any type of clinical trial, the NIH is a wonderful resource: https://goo.gl/WEf3gR